Tissue Bioengineering

Bioengineering Beige Adipose Tissue Therapeutics

Unlocking the therapeutic potential of brown/beige adipose tissue requires technological advancements that enable the controlled expansion of this uniquely thermogenic tissue. Transplantation of brown fat in small animal model systems has confirmed the expectation that brown fat expansion could possibly provide a novel therapeutic to combat obesity and related disorders. Expansion and/or stimul...

Bioengineering of Colo-Rectal Tissue

Bioengineering Human Scaffold-free Cartilage Constructs Using Paediatric Auricular Tissue

Currently, patients with external ear deformities rely on hyaline cartilage grafts or silicone prosthesis to provide them with adequate external ear reconstruction. Scaffold-free auricular tissue engineering provides a means of creating patient specific cartilage constructs solely using their own cells, ensuring biocompatibility, long term stability, and reduced morbidity. Here, we have develop...

Microengineering hydrogels for stem cell bioengineering and tissue regeneration.

The integration of microfabrication technologies with advanced biomaterials has led to the development of powerful tools to control the cellular microenvironment and the microarchitecture of engineered tissue constructs. Here we review this area, with a focus on the work accomplished in our laboratory. In particular, we discuss techniques to develop hydrogel microstructures for controlling cell...

Temporomandibular Joint Reconstruction: from Alloplastic Prosthesis to Bioengineering Tissue

Pain and dysfunction of the temporomandibular joint (TMJ) may affect more than 10 percent of the adult people in developed countries. TMJ is a unique jaw joint with both rotational and translational movements while masticating, swallowing or speaking. During masticatory function, the both-side joints work in harmony with adjacent structures including masticatory muscles, teeth (occlusion), tong...